Repetitive Daily Blindness with Hemiplegic Migraine and SCN1A Mutations

Sporadic Hemiplegic Migraine with ATP1A2 and Prothrombin Gene Mutations

Background. Hemiplegic migraine is a rare type of migraine that may present in children and adolescents. Both familial and sporadic hemiplegic migraines have similar prevalence and clinical characteristics. Patient. We report an adolescent with sporadic hemiplegic migraine who previously had a similar attack in the past and who was initially evaluated for a possible acute ischemic event. Result...

Early-onset familial hemiplegic migraine due to a novel SCN1A mutation

Introduction Familial hemiplegic migraine (FHM) is a rare autosomal dominant subtype of migraine with aura. The FHM3 subtype is caused by mutations in SCN1A, which is also the most frequent epilepsy gene encoding the voltage-gated Na+ channel NaV1.1. The aim of this study was to explore the clinical, genetic and pathogenetic features of a pure FHM3 family. Methods A three-generation family was ...

EVALUATION OF PATIENTS WITH HEMIPLEGIC MIGRAINE IN MACKENZIE HEADACHE CLINIC

Background: The sporadic type of Hemiplegic Migraine (HM) is sometimes observed among migrainous patients (MP) and mimics ischemic strokes. Methods: In an evaluation of two-hundred consecutive adult MP in the Mackenzie headache clinic, Canada during 2004 , 9% of the patients met the criteria established by the International Headache Society for sporadic HM. Female to male sex ratio, family...

Familial hemiplegic migraine.

EEG in hemiplegic migraine.

A 17-year-old boy developed diffuse throbbing headache of 36 hours duration associated with photophobia and phonophobia. Twelve hours later, he developed dysarthria and rightsided weakness. He had a similar episode 5 months ago with resolution of symptoms in 24 hours, following which he was put on prophylactic sodium valproate 300 mg/day. His elder brother had suffered from intermittent diffuse...